論文リスト（抜粋）

*すべての論文は[コチラ]

  1. Obashi, K., Matsuda, A., Inoue, Y., and S. Okabe. Precise temporal regulation of molecular diffusion within dendritic spines by actin polymers during structural plasticity. Cell Reports in press.
  2. Kashiwagi, Y., Higashi, T., Obashi, K., Sato, Y., Komiyama, N., Grant, S. G. N. and S. Okabe. Computational geometry analysis of dendritic spines by structured illumination microscopy Nature Communications 2019 Mar 20;10(1):1285. doi: 10.1038/s41467-019-09337-0.
  3. Urata, S., Iida, T., Yamamoto, M., Mizushima, Y., Fujimoto, C., Matsumoto, Y., Yamasoba, T. and S. Okabe. Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning. eLIFE 2019 Jan 18;8. pii: e40946. doi: 10.7554/eLife.40946..
  4. Iida, T., Tanaka, S., and S. Okabe. Spatial impact of microglial distribution on dynamics of dendritic spines European Journal of Neuroscience 2018 Dec 26. doi: 10.1111/ejn.14325. [Epub ahead of print]
  5. Tzeng, T-C, Hasegawa, Y., Iguchi, R., Caffrey, D. R., Thatcher, E. J., Mao, W.J., Germain, G., Tamburro, N. D., Okabe, S., Heneka, M., Latz, E., Futai, K., and D. T. Golenbock. The inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer’s prone mice. Proc. Natl. Acad. Sci. USA 115(36):9002-9007, 2018. doi: 10.1073/pnas.1801802115.
  6. Nakayama, H., Abe, M., Morimoto, C., Iida, T., Okabe, S., Sakimura, K., and K. Hashimoto. Microglia permit climbing fiber elimination by promoting GABAergic inhibition in the developing cerebellum. Nature Communications9:2830, 2018. doi: 10.1038/s41467-018-05100-z
  7. Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, Tanaka KF, Liu X, and TJ McHugh. Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics. Science. 359:679-684, 2018. doi: 10.1126/science.aaq1144.
  8. Higashi T, Tanaka S, Iida T, and S. Okabe. Synapse elimination triggered by BMP4 exocytosis and presynaptic BMP receptor activation. Cell Reports 22(4):919-929, 2018. doi: 10.1016/j.celrep.2017.12.101
  9. Morimoto, M. Tanaka, S., Mizutani, S., Urata, S., Kobayashi, K. and S. Okabe. In vivo observation of structural changes in neocortical catecholaminergic projections in response to drugs of abuse eNeuro 6;5(1),2018. pii: ENEURO.0071-17.2018. doi: 10.1523/ENEURO.0071-17.2018.
  10. Koeberle, S. C., Tanaka, S., Kuriu, T., Iwasaki, H., Koeberle, A., Schulz, A., Helbing, D., Yamagata, Y., Morrison, H., and S. Okabe. Developmental stage-dependent regulation of spine formation by calcium-calmodulin dependent protein kinase IIα and Rap1 Scientific Reports 7, 13409, 2017, doi: 10.1038/s41598-017-13728-y
  11. Isshiki, M., Tanaka, S., Kuriu, T., Tabuchi, K., Takumi, T. and S. Okabe. Enhanced synapse remodelling as a common phenotype in mouse models of autism. Nature Communications 5, 4742, 2014. doi: 10.1038/ncomms5742.
  12. Obashi, K. and S. Okabe. Regulation of mitochondrial dynamics and distribution by synapse position and neuronal activity in the axon. European Journal of Neuroscience 38(3), 2350-2363, 2013.
  13. Okabe, S. Fluorescence imaging of synapse formation and remodeling. Microscopy 62(1), 51-62, 2013.
  14. Shin E., Kashiwagi, Y., Kuriu, T., Iwasaki, H., Tanaka, T., Koizumi, H., Gleeson, G.J., S. Okabe. Doblecortin-like kinase enhances dendrite remodelling and negatively regulates synapse maturation. Nature Communications 4, 1440, 2013.
  15. Ito-Ishida A, Miyazaki T, Miura E, Matsuda K, Watanabe M, Yuzaki M and S. Okabe. Presynaptically Released Cbln1 Induces Dynamic Axonal Structural Changes by Interacting with GluD2 during Cerebellar Synapse Formation. Neuron 76, 549-64, 2012.
  16. Kawabata, I., Kashiwagi, Y., Obashi, K., Ohkura, M., Nakai, J., Wynshaw-Boris, A., Yanagawa, Y., and S. Okabe. LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites. Nature Communications 3, 722, 2012.
  17. Kondo, S., Kohsaka, S., and S. Okabe. Long-term changes of spine dynamics and microglia after transient peripheral immune response triggered by LPS in vivo. Molecular Brain 4, 27, 2011.
  18. Numano, F., Inoue, A., Enomoto, M., Shinomiya, K., Okawa, A., and S. Okabe. Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord. Molecular Brain 2, 37, 2009.
  19. Yamagata, Y., Kobayashi, S., Umeda, T., Inoue, A., Sakagami, H., Fukaya, M., Watanabe, M., Hatanaka, N., Totsuka, M., Yagi, T., Obata, K., Imoto, K., Yanagawa, Y., Manabe, T. and S. Okabe. Kinase-dead knock-in mouse reveals an essential role of CaMKIIa kinase activity in dendritic spine enlargement, LTP and learning. Journal of Neuroscience, 29, 7607-7618, 2009.
  20. Okabe, S.  Molecular anatomy of the postsynaptic density. Molecular and Cellular Neuroscience 34, 503-518, 2007.
  21. Nishida, H. and S. Okabe. Direct astrocytic contacts regulate local maturation of dendritic spines. Journal of Neuroscience 27, 331-340, 2007.
  22. Kuriu, T., Inoue, A., Bito, H., Sobue, K., and S. Okabe. Differential control of postsynaptic density scaffolds via actin-dependent and independent mechanisms. Journal of Neuroscience 26, 7693-7706, 2006.
  23. Iki, J., Inoue, A., Bito, H., and S. Okabe Bi-directional regulation of postsynaptic cortactin distribution by BDNF and NMDA receptor activity.
    European Journal of Neuroscience 22, 2985-2994, 2005.
  24. Sugiyama, Y., Kawabata, I., Sobue, K., and S. Okabe. Determination of absolute protein numbers in single synapses by a GFP-based calibration technique. Nature Methods 2, 677-684, 2005.
  25. Fujii, R.*, Okabe, S.*, Urushido, T., Inoue, K., Yoshimura, A., Tachibana, T., Nishikawa, T., Hick, G. G., and T. Takumi * equal contribution The RNA-binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology. Current Biology 15, 587-593, 2005.
  26. Yamamoto, K., Yamaguchi, M., and S. Okabe Direct visualization of cell movement in the embryonic olfactory bulb using green fluorescent protein transgenic mice: evidence for rapid tangential migration of neural cell precursors. Neuroscience Research, 51, 199-214, 2005.
  27. Umeda, T., Ebihara, T., and S. Okabe Simultaneous observation of stably associated presynaptic varicosities and postsynaptic spines: morphological alterations of CA3-CA1 synapses in hippocampal slice cultures. Molecular and Cellular Neuroscience, 28, 264-274, 2005.
  28. Inoue A., and S. Okabe The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function. Current Opinion in Neurobiology, 13, 332-340, 2003.
  29. Ebihara, T., Kawabata, I., Usui, S., Sobue, K., and S. Okabe. Synchronized formation and remodeling of postsynaptic densities: long-term visualization of hippocampal neurons expressing postsynaptic density proteins tagged with GFP. Journal of Neuroscience, 23, 2170-2181, 2003.
  30. Nakatomi, H., Kuriu, T., Okabe, S., Yamamoto, S., Hatano, O., Kawahara, N., Tamura, A., Kirino, T. and M. Nakafuku. Regeneration of hippocampal pyramidal neurons by recruitment of endogenous neural progenitors: An animal model for a neuronal replacement therapy for ischemic brain injury. Cell, 110, 429-441, 2002.
  31. Okabe, S., Urushido, T., Konno, D., Okado, H., and K. Sobue. Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels. Journal of Neuroscience, 21,9561-9571,2001.
  32. Okabe, S., Miwa, A., and H. Okado. Spine formation and correlated assembly of presynaptic and postsynaptic molecules. Journal of Neuroscience, 21, 6105-6114, 2001.
  33. Okabe, S., Kim, H., Miwa, A., Kuriu, T., and H. Okado. Continual remodeling of postsynaptic density and its regulation by synaptic activity. Nature Neuroscience, 2, 804-811, 1999.
  34. Okabe, S., Miwa, A., and H. Okado. Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit. Journal of Neuroscience, 19, 7781-7792, 1999.
  35. Okabe, S., Collin, C., Auerbach, J. M., Meiri, N., Bengzon, J., Kennedy, M. B., Segal, M., and R. D. G. McKay. Hippocampal synaptic plasticity in mice overexpressing an embryonic subunit of the NMDA receptor.  Journal of Neuroscience, 18, 4177-4188, 1998.
  36. Brustle, O., Spiro, A.C., Karram, K., Choudhary, K., Okabe, S., and R. D. G. McKay. In vitro-generated neural precursors participate in mammalian brain development. Proc. Natl. Acad. Sci. USA, 94, 14809-14814, 1997.
  37. Okabe, S., Forsberg-Nilsson, K., Spiro, A. C., Segal, M. and R. D. G. McKay. Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mechanisms of Development, 59, 89-102, 1996.
  38. Harada, A., Oguchi, K., Okabe, S., Kuno, J., Terada, T., Oshima, T., Sato-Yoshitake, R., Takei, Y., Noda, T. and N. Hirokawa. Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature, 369, 488-491, 1994.
  39. Okabe, S., Miyasaka, H., and N. Hirokawa. Dynamics of the neuronal intermediate filaments. Journal of Cell Biology, 121, 375-386, 1993.
  40. Okabe, S. and N. Hirokawa. Do photobleached fluorescent microtubules move?:re-evaluation of fluorescence laser photobleaching both in vitro and in growing Xenopus axon. Journal of Cell Biology, 120, 1177-1186, 1993.
  41. Okabe, S. and N. Hirokawa. Differential behavior of photoactivated microtubules in growing axon of mouse and frog neurons. Journal of Cell Biology, 117, 105-120, 1992.
  42. Okabe, S. and N. Hirokawa. Actin dynamics in growth cones. Journal of Neuroscience, 11, 1918-1929, 1991.
  43. Okabe, S. and N. Hirokawa. Turnover of fluorescently labelled tubulin and actin in the axon. Nature, 343, 479-482, 1990.
  44. Okabe, S. and N. Hirokawa. Incorporation and turnover of biotin-labeled actin microinjected into fibroblastic cells: an immunoelectron microscopic study. Journal of Cell Biology, 109, 1581-1595, 1989.
  45. Okabe, S. and N. Hirokawa. Rapid turnover of microtubule-associated protein MAP2 in the axon revealed by microinjection of biotinylated MAP2 into cultured neurons. Proc. Natl. Acad. Sci. USA, 86, 4127-4131, 1989.
  46. Okabe, S. and N. Hirokawa. Microtubule dynamics in nerve cells: analysis using microinjection of biotinylated tubulin into PC12 cells. Journal of Cell Biology, 107, 651-664, 1988.
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